Agent-based models for actomyosin contractility and cortical flow

We are using agent-based models to explore how microscopic interactions among actin filaments, crosslinking proteins and myosin motors give rise to macroscopic dynamics of contractility and cortical flow, and how the microscopic properties can be tuned to produce functional variation in the macroscopic dynamics, as observed in living cells or in vitro experiments with purified proteins.  Our recent efforts have focused on understanding how the tunable properties of myosin motors shape force buildup and transmission in contractile networks and how actin turnover allows contractile networks continuously build and dissipate force to drive rapid network remodeling and cortical flow.